Streptomyces is renowned for its abundant production of bioactive secondary metabolites. but most of these natural products are produced in low yields. Traditional rational network refactoring is highly dependent on the comprehensive understanding of regulatory mechanisms and multiple manipulations of genome editing. Though random mutagenesis is fairly straightforward. https://www.ngetikin.com/limited-save-Apple-iPhone-14-Pro-Clear-Case-with-MagSafe-save-big/