Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here. we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice. Specific inhibition of deubiquitinases ubiquitin-specific peptidase 14 (USP14) resulted in durable tumor regressions of autochthonous lymphoma... https://www.knowall.blog/